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Best Performing Penny Stocks of 2022 USA

Updated Nov 22, 2022
Investing and trading in penny stocks can be extremely risky, as majority of the stocks which are trading at extremely low prices may still go down further. Extreme results can be a complete bankruptcy of the listed stock's company. Investors still like to take the risk trying to hunt for low-cost stocks today which can become the super stars of tomorrow. They try to buy a few of the low-cost stocks at low prices today, and even if one or two of those investments turn out to be multi-baggers, their returns are substantial. Penny stocks are those which are trading at a per share price of below $5. Among the various stocks of the U.S.-listed companies, which ones have been the front-runners in terms of generating the highest returns for the investors? Here is the list comprising of those top 10 America-listed stocks, industry or business segment (or index), which have generated the best returns in terms of price changes between the end of previous year and the date of writing.
However, one must note that owing to various reasons, like very little trading or lack of proper coverage for data content on penny stocks, the list of top performing stocks may not be accurate, and errors and omissions may be expected.

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Top Performing Penny StocksAll Penny StocksTop Penny Stocks for Nov 2022

Top Penny Stocks With Highest Returns

The following list presents stocks of the companies which belong to the broader Penny sector or the stock market index, their corresponding prices as of given date, and the percentage gains realized:
 1) Palatin Technologies, Inc. (PTN) 2) Kintara Therapeutics, Inc. (KTRA) 3) Torchlight Energy Resources, Inc. (TRCH) 4) Trevena, Inc. (TRVN) 5) NovaBay Pharmaceuticals, Inc. (NBY)
 6) LAIX Inc. (LAIX) 7) Aileron Therapeutics, Inc. (ALRN) 8) Hoth Therapeutics, Inc. (HOTH) 9) AcelRx Pharmaceuticals, Inc. (ACRX) 10) Happiness Biotech Group Ltd (HAPP)
There's more... See price performance, YTD-gains, market-cap and other details of all the Penny stocks with sorting features in a tabular format.
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Top Performing Penny StocksAll Penny StocksTop Penny Stocks for Nov 2022

Performance of Top Penny Stocks

Here's a look at the basic details and how the above mentioned stocks fared during the period:

Palatin

Palatin Technologies, Inc., incorporated on November 21, 1986, is a biopharmaceutical company. The Company is engaged in developing targeted, receptor-specific peptide therapeutics for the treatment of diseases with significant unmet ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of Palatin.
The New Jersey, NJ-based Palatin Technologies, Inc. (PTN) belongs to the Healthcare sector and is categorized as a Major Pharmaceuticals company. The stock of Palatin ended the previous year at a price of $0.55 per share. As of Nov 22, 2022, the stock price has reached $3.99 apiece, which indicates a change of 629.17 percent making the company rank among the top performing stocks of the Penny for the year 2022 till date. At the end of the last year, company's market capitalization stood at $126.59 million. It has now changed to $41.31 million as of writing. Palatin continues to be a leading constituent of many major stock market indexes like Wilshire 5000 index, and several other broader level multi-cap market indicators.

Kintara Therapeutics, Inc.

Kintara Therapeutics, Inc., a clinical stage drug development company, focuses on developing and commercializing anti-cancer therapies to treat cancer ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of Kintara Therapeutics, Inc..
At number two in the list of top stocks stands Kintara Therapeutics, Inc. (KTRA), which saw a change in its stock price from the level of $0.52 apiece during previous year December end to the price of $3.75 per share as of Nov 22, 2022. It translates to a change of 618.39 percentage. The San Diego, United States-headquartered Healthcare sector company also saw its market value change from $25.34 million to $6.06 million.

Torchlight Energy Resources

Torchlight Energy Resources, Inc. (Torchlight), incorporated on October 30, 2007, is engaged in the acquisition, exploration, exploitation, and/or development of oil and natural gas properties in the United States. The ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of Torchlight Energy Resources.
The Texas, TX-headquartered company Torchlight Energy Resources, Inc. (TRCH) is ranked number three among the best performing stocks of Penny of 2022. The Energy sector business falls under the Oil & Gas E&P industrial sub-sector. Since the start of the year 2022, the stock price of Torchlight Energy Resources has changed by 607.14 percent, which is calculated based on the previous year's closing price of $0.7 per share and year-to-date closing price of $4.95 per share as of writing. The market value of the company as indicated by its market-cap changed from $69.75 million to $788.32 million during the same period. Along with Penny, the company is also in the business of Energy, Oil and Gas Production, Oil & Gas E&P, Oil, Wilshire 5000, among other usual products and services. Torchlight Energy Resources continues to be a leading constituent of many major stock market indexes like Wilshire 5000 index, and a few other larger indexes which are part of the stock market.

Trevena

Trevena Inc., incorporated on November 9, 2007, is a biopharmaceutical company, which is engaged in developing various therapies. The Company is developing OLINVO, a u-receptor G protein pathway selective modulator ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of Trevena.
During the given months of the year 2022, Trevena, Inc. (TRVN) was successful in generating YTD returns of 504.99 percentage which helped it gain the number four spot in the list of the top performing stocks which generated maximum returns during year 2022 till date. As of December of the previous year, the stock of the Pennsylvania, PA-based Trevena closed at a price of $0.6 per share, while it traded at a price of $3.61 per share as of Nov 22, 2022. The company's market cap changed from $98.17 million to $25.09 million during the same period YTD. It ranks as a key constituent of major indexes that include Wilshire 5000 index, and several other broader level multi-cap market indicators. The company is classified under the Healthcare industry sector and further specialized as a Major Pharmaceuticals sector business.

NovaBay Pharma

NovaBay Pharmaceuticals, Inc., formerly NovaCal Pharmaceuticals, Inc., incorporated on April 19, 2010, is a biopharmaceutical company, which develops products for the eye care market. The Company focuses on commercializing prescription ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of NovaBay Pharma.
Rank number five in the coveted list is held by NovaBay Pharmaceuticals, Inc. (NBY) for being among the top performing stocks of 2022. Headquartered in California, CA, the Healthcare sector company is categorized under the industrial sub-sector of Major Pharmaceuticals. Since the start of the year 2022, stock of NovaBay Pharma has so far gained 500.31 percentage, based on the previous year's closing price of $0.39 per share and year-to-date price of $2.34 per share. During the same period, the market capitalization of the company changed from $17.53 million to $4.35 million. The stock of NovaBay Pharma continues to be a major constituent of many leading stock indexes which include Wilshire 5000 index, and several other broader level multi-cap market indicators.

LAIX

LAIX Inc., an artificial intelligence company, provides online English learning services through Liulishuo mobile app in the People's Republic of China. It is also involved in the artificial intelligence lab op ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of LAIX.
The number six spot in the list of top performing stocks of the Penny sector is taken by LAIX Inc. (LAIX). The company's stock price changed from $0.57 per share at the end of December of the previous year to the price of $3.1 per share as of writing. Overall, the stock managed to realized price change of 445.29 percent during the given time period. The corresponding change in the market capitalization value of the Shanghai, -based Consumer Defensive sector company was from $28.37 million to $11.05 million. Being ranked in the top 10 best performing stocks of the Penny sector, the company also succeeded in outperforming the returns generated by some of the popular stock market indexes.

Aileron Therapeutics

Aileron Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing and commercializing a novel class of therapeutics in the United States. The company's lead product candidate is ALRN ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of Aileron Therapeutics.
Aileron Therapeutics, Inc. (ALRN) has moved by 420.91 percentage over the given period of 2022-YTD, helping it gain a place at number seven among the top performing stocks. The Healthcare sector company managed to achieve the feat as its stock price changed from $0.54 apiece to the price of $2.79 per share between the end of December of the previous year and Nov 22, 2022. The smart run of the Watertown, MA-based Healthcare sector company lead to a handsome gain in its marketcap which changed from $48.51 million to $12.67 million over the same duration.

Hoth Therapeutics

Hoth Therapeutics, Inc., a biopharmaceutical company, focuses on developing targeted therapeutics for eczema, dermatological and chronic wound disorders, psoriasis, and acne. It intends to use the BioLexa Platform to develop 2 topical cream products that treat eczema and reduces post-procedure infections for patients undergoing aesthetic dermatology procedures. The company has a sponsored research agre ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of Hoth Therapeutics.
Hoth Therapeutics (HOTH) generated percentage returns of 402.17 percent during the 2022 year-to-date. Its returns are based on the share price which moved from $0.69 per share from the previous year-end to the price of $3.47 per share as of Nov 22, 2022. The company's value, as indicated by the market-cap figure, changed from $16.57 million to $4.51 million during the same period.
The company is categorized as a Healthcare speciality business with further classification in the Biotechnology sub-category. Based in New York, NY, the YTD performance of the Penny sector also fared better than that of the returns generated by some of the closley tracked stock market indexes.

AcelRx Pharma

AcelRx Pharmaceuticals, Inc., incorporated on July 13, 2005, is a specialty pharmaceutical company focused on the development and commercialization of therapies for the treatment of moderate-to-severe acute pain. The Company ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of AcelRx Pharma.
The California, CA-based Healthcare sector company AcelRx Pharmaceuticals, Inc. (ACRX) holds the number nine spot among the best performing stocks of the Penny sector. Classified as the Major Pharmaceuticals business, the stock price of AcelRx Pharma ended the previous year at a price of $0.49 per share while it reached the level of $2.21 apiece as of Nov 22, 2022 translating to a percentage change in stock price of 350.74%. As of writing, the company's market-cap value stands at $16.46 million. Few leading stock market index includes AcelRx Pharma in their constituent list. They include Wilshire 5000 index, and a few other larger indexes which are part of the stock market.

Happiness Biotech Group

Happiness Biotech Group Limited engages in the research, development, manufacture, and sale of nutraceutical and dietary supplements products made of Lucidum spore powder and others in the People's Republic of China. It also offers edible fungi. The company was founded in 2004 and is based in Nanping, China. ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of Happiness Biotech Group.
Based on the market-cap change from $17.73 million to $9.85 million during the given months of the year 2022 and the share price change from $0.56 per share to a price of $2.49 per share as of Nov 22, 2022, Happiness Biotech Group Ltd (HAPP) was successful in generating YTD returns of 348.65 percentage. Standing at the number ten rank in the top performing list of Penny stocks, the Nanping, -based Happiness Biotech Group is categorized as the Drug Manufacturer sub-sector business which falls under the larger Healthcare sector.
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