Best Performing Healthcare Penny Stocks 2025 USA: FKnol.com

The healthcare sector often produces many high return generating companies, as stocks of the companies working in the pharma, drug discovery, research or associated business have the potential to emerge as winners. Say, if after few years of research work, a small drug research company is able to develop a cure for an ailment or disease which can result in big profits due to patent, copyright and other clauses. The stock price of such a company will shoot through the roof the day it tastes success. Pharma and health sector offers this great potential for producing many multi-bagger stocks. Therefore, investors who are good to make such small-priced bets on such economical-looking, low-cost healthcare stocks do so in expectations of high rewards in the future. These constitute the healthcare penny stocks.
However, one must note that not all such penny stock investments taste success. Majority of them fail, but those which do win offer big potential of not only recouping the losses of losers but also offering great surplus profits.
Penny stocks are those which are trading at a per share price of below $5. Among the various stocks of the U.S.-listed companies belonging to the Healthcare Penny segment, which ones have been the front-runners in terms of generating the highest returns for the investors? Here is the following list comprising of those top 10 America-listed stocks of the 'Healthcare Penny' sector, industry or business segment (or index), which have generated the best returns in terms of price changes between the end of previous year and the date of writing.

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Top Performing Healthcare Penny StocksAll Healthcare Penny StocksTop Healthcare Penny Stocks for May 2025

Top Healthcare Penny Stocks With Highest Returns

The following list presents stocks of the companies which belong to the broader Healthcare Penny sector or the stock market index, their corresponding prices as of given date, and the percentage gains realized:

1) Assure Holdings Corp. (IONM)

Price Gain: 1,641.18% 2025 year-to-date
Current Market Price: $4.44
52-week Price Range: $3.6 - $17.64
Market Capitalization: $2.22 million

2) BioLineRx Ltd. (BLRX)

Price Gain: 1,371.43% 2025 year-to-date
Current Market Price: $3.09
52-week Price Range: $2.3 - $35.6
Market Capitalization: $11.97 million
List of ETFs holding BLRX

3) Bionano Genomics, Inc. (BNGO)

Price Gain: 1,255.17% 2025 year-to-date
Current Market Price: $3.93
52-week Price Range: $2.68 - $72.6
Market Capitalization: $12.19 million
List of ETFs holding BNGO

4) Minerva Surgical, Inc. (UTRS)

Price Gain: 1,162.31% 2025 year-to-date
Current Market Price: $2.82
52-week Price Range: $1.55 - $14
Market Capitalization: $25.04 million

5) Tivic Health Systems, Inc. (TIVC)

Price Gain: 1,134.29% 2025 year-to-date
Current Market Price: $4.32
52-week Price Range: $2.43 - $16.08
Market Capitalization: $3.79 million

6) Biomerica, Inc. (BMRA)

Price Gain: 1,123.33% 2025 year-to-date
Current Market Price: $3.67
52-week Price Range: $1.93 - $10.16
Market Capitalization: $9.35 million
List of ETFs holding BMRA

7) CNS Pharmaceuticals, Inc. (CNSP)

Price Gain: 950.00% 2025 year-to-date
Current Market Price: $1.26
52-week Price Range: $0.77 - $800
Market Capitalization: $3.71 million
List of ETFs holding CNSP

8) China Pharma Holdings, Inc. (CPHI)

Price Gain: 882.61% 2025 year-to-date
Current Market Price: $2.26
52-week Price Range: $1.2 - $4.1
Market Capitalization: $7.37 million
List of ETFs holding CPHI

9) The Oncology Institute, Inc. (TOI)

Price Gain: 880.65% 2025 year-to-date
Current Market Price: $3.04
52-week Price Range: $0.13 - $3.5
Market Capitalization: $266.79 million

10) CERo Therapeutics Holdings, Inc. (CERO)

Price Gain: 866.67% 2025 year-to-date
Current Market Price: $0.58
52-week Price Range: $0.53 - $117.76
Market Capitalization: $3.63 million

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Top Performing Healthcare Penny StocksAll Healthcare Penny StocksTop Healthcare Penny Stocks for May 2025

Performance of Top Healthcare Penny Stocks

Here's a look at the basic details and how the above mentioned stocks fared during the period:

Assure Holdings Corp.

Assure Holdings Corp., together with its subsidiaries, provides technical and professional intraoperative neuromonitoring surgical support services ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of Assure Holdings Corp..
Assure Holdings Corp. (IONM) has moved by 1641.18 percentage over the given period of 2025-YTD, helping it gain a place at number one among the top performing stocks. The Healthcare sector company managed to achieve the feat as its stock price changed from $0.26 apiece to the price of $4.44 per share between the end of December of the previous year and May 15, 2025. The smart run of the Denver, United States-based Medical Care Facilities sector company lead to a handsome gain in its marketcap which changed from $1.71 million to $2.22 million over the same duration.

BioLineRx

BioLine RX Ltd is an Israel-based company engaged in the development of therapeutics, from preclinical-stage development to advanced clinical trials, for a range of medical needs. Its clinical therapeutic candidates ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of BioLineRx.
The number two spot in the list of top performing stocks of the Healthcare Penny sector is taken by BioLineRx Ltd. (BLRX). The company's stock price changed from $0.21 per share at the end of December of the previous year to the price of $3.09 per share as of writing. Overall, the stock managed to realized price change of 1371.43 percent during the given time period. The corresponding change in the market capitalization value of the Israel-based Healthcare sector company was from $113.73 million to $11.97 million. Being ranked in the top 10 best performing stocks of the Healthcare Penny sector, the company also succeeded in outperforming the returns generated by some of the popular stock market indexes.

Bionano Genomics

Bionano Genomics, Inc. operates as a life sciences instrumentation company in the genome analysis space. The company develops and markets the Saphyr system, a platform for ultra-sensitive and ultra-specific str ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of Bionano Genomics.
Bionano Genomics (BNGO) generated percentage returns of 1255.17 percent during the 2025 year-to-date. Its returns are based on the share price which moved from $0.29 per share from the previous year-end to the price of $3.93 per share as of May 15, 2025. The company's value, as indicated by the market-cap figure, changed from $73.41 million to $12.19 million during the same period.
The company is categorized as a Healthcare speciality business with further classification in the Healthcare sub-category. Based in San Diego, CA, the YTD performance of the Healthcare Penny sector also fared better than that of the returns generated by some of the closley tracked stock market indexes.

Minerva Surgical, Inc.

Minerva Surgical Inc., a commercial-stage medical technology company, focuses on developing, manufacturing, and commercializing minimally invasive ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of Minerva Surgical, Inc..
The Santa Clara ,United States-based Healthcare sector company Minerva Surgical, Inc. (UTRS) holds the number four spot among the best performing stocks of the Healthcare Penny sector. Classified as the Health Information Services business, the stock price of Minerva Surgical, Inc. ended the previous year at a price of $0.22 per share while it reached the level of $2.82 apiece as of May 15, 2025 translating to a percentage change in stock price of 1162.31%. As of writing, the company's market-cap value stands at $25.04 million.

Tivic Health Systems, Inc.

Tivic Health Systems Inc. operates as a bioelectronic device company that delivers non-invasive neuromodulation products for the treatment of inflammatory ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of Tivic Health Systems, Inc..
Based on the market-cap change from $2.64 million to $3.79 million during the given months of the year 2025 and the share price change from $0.35 per share to a price of $4.32 per share as of May 15, 2025, Tivic Health Systems, Inc. (TIVC) was successful in generating YTD returns of 1134.29 percentage. Standing at the number five rank in the top performing list of Healthcare Penny stocks, the Newark ,United States-based Tivic Health Systems, Inc. is categorized as the Medical Devices sub-sector business which falls under the larger Healthcare sector.

Biomerica

Biomerica, Inc., incorporated on September 22, 1971, is a biomedical company, which develops, manufactures and markets medical diagnostic products for the early detection and monitoring of chronic diseases and medical ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of Biomerica.
The California, CA-headquartered company Biomerica, Inc. (BMRA) is ranked number six among the best performing stocks of Healthcare Penny of 2025. The Healthcare sector business falls under the Medical Dental Instruments industrial sub-sector. Since the start of the year 2025, the stock price of Biomerica has changed by 1123.33 percent, which is calculated based on the previous year's closing price of $0.3 per share and year-to-date closing price of $3.67 per share as of writing. The market value of the company as indicated by its market-cap changed from $21.03 million to $9.35 million during the same period. Along with Healthcare Penny, the company is also in the business of Health Care, Medical Dental Instruments, Diagnostics & Research, Healthcare, among other usual products and services.

CNS Pharmaceuticals

CNS Pharmaceuticals, Inc., a preclinical stage pharmaceutical company, focuses on the development of anti-cancer drug candidates for the treatment of primary and metastatic brain, and central nervous system tumors. Its lead drug candidate is Berubicin, which completed Phase I clinical trial that is used for the treatment of glioblastoma. The company was founded in 2017 and is based in Houston, Texas. ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of CNS Pharmaceuticals.
During the given months of the year 2025, CNS Pharmaceuticals, Inc. (CNSP) was successful in generating YTD returns of 950 percentage which helped it gain the number seven spot in the list of the top performing stocks which generated maximum returns during year 2025 till date. As of December of the previous year, the stock of the Houston, TX-based CNS Pharmaceuticals closed at a price of $0.12 per share, while it traded at a price of $1.26 per share as of May 15, 2025. The company's market cap changed from $7.89 million to $3.71 million during the same period YTD. The company is classified under the Healthcare industry sector and further specialized as a Biotechnology sector business.

China Pharma

China Pharma Holdings, Inc., incorporated on January 28, 1999, is a holding company. The Company conducts its production, marketing, finance, development and administrative activities through its subsidiary, Hainan Helpson Medical ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of China Pharma.
Rank number eight in the coveted list is held by China Pharma Holdings, Inc. (CPHI) for being among the top performing stocks of 2025. Headquartered in China, the Healthcare sector company is categorized under the industrial sub-sector of Major Pharmaceuticals. Since the start of the year 2025, stock of China Pharma has so far gained 882.61 percentage, based on the previous year's closing price of $0.23 per share and year-to-date price of $2.26 per share. During the same period, the market capitalization of the company changed from $3.99 million to $7.37 million.

The Oncology Institute, Inc.

The Oncology Institute, Inc., an oncology company, provides medical oncology services in the United States. Its services include physician services, ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of The Oncology Institute, Inc..
At number nine in the list of top stocks stands The Oncology Institute, Inc. (TOI), which saw a change in its stock price from the level of $0.31 apiece during previous year December end to the price of $3.04 per share as of May 15, 2025. It translates to a change of 880.65 percentage. The Cerritos, United States-headquartered Healthcare sector company also saw its market value change from $150.45 million to $266.79 million.

CERo Therapeutics Holdings

CERo Therapeutics Holdings, Inc., an immunotherapy company, focuses on advancing the development of engineered T cell therapeutics for the treatment of ... see Detailed Company Profile, full Dividend History, and List of ETFs holding the stock of CERo Therapeutics Holdings.
The South San Francisco, CA-based CERo Therapeutics Holdings, Inc. (CERO) belongs to the Healthcare sector and is categorized as a Biotechnology company. The stock of CERo Therapeutics Holdings ended the previous year at a price of $0.06 per share. As of May 15, 2025, the stock price has reached $0.58 apiece, which indicates a change of 866.67 percent making the company rank among the top performing stocks of the Healthcare Penny for the year 2025 till date. At the end of the last year, company's market capitalization stood at $0 million. It has now changed to $3.63 million as of writing.

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